Axayacatl was the sixth tlatoani of the altepetl of Tenochtitlan and Emperor of the Aztec Triple Alliance.

Tlahtoāni is a historical title used by the dynastic rulers of āltepēmeh, autonomous political entities formed by many pre-Colombian Nahuatl-speaking peoples in the Valley of Mexico during the Postclassic Period. The title of huēyi tlahtoāni was used by the rulers of the Aztec Empire, an alliance between the āltepēmeh of Tenochtitlan, Tetzcoco, and Tlacopan.