Ayeyarwady Region is a region of Myanmar, occupying the delta region of the Ayeyarwady River. It is bordered by the Rakhine State to the northwest, the Bago Region to the north, Bago Region and Yangon Region to the east, and the Bay of Bengal to the south and west.

The Irrawaddy River is the largest river in Myanmar. Originating from the confluence of the N'mai and Mali rivers, it flows from north to south before emptying through the Irrawaddy Delta in the Ayeyarwady Region into the Andaman Sea. Its drainage basin of about 404,000 square kilometres (156,000 sq mi) covers 61% of the land area of Burma, and contains five of its largest cities.