Ayrshire is a historic county and registration county in south-west Scotland, located on the shores of the Firth of Clyde. Its principal towns include Ayr and Irvine and it borders the counties of Renfrewshire and Lanarkshire to the north-east, Dumfriesshire to the south-east, Kirkcudbrightshire and Wigtownshire to the south. Like many other counties of Scotland it has no administrative function, instead being sub-divided into the council areas of North Ayrshire, South Ayrshire and East Ayrshire, it has a population of 366,800. The electoral and valuation area named Ayrshire covers the three council areas of South Ayrshire, East Ayrshire and North Ayrshire, therefore including the Isle of Arran, Great Cumbrae and Little Cumbrae; these three islands are part of the County of Bute and are sometimes included when the term Ayrshire is applied to the region. The same area is known as Arran in other contexts. Ayrshire is crescent-shaped and is a predominantly flat county with areas of low hills; the north of the county contains bulk of the population.

East of Largs can be found the Renfrewshire Heights, which continue south to the hill-country around Blae Loch. Southern Ayrshire shares with the Galloway counties some rugged hill country known as the Galloway Hills; these hills lie to the west of the A713 and they run south from the Loch Doon area to the Solway Firth. To the east of this route through the hills lie the Carsphairn and Scaur Hills which lie to the south east of Dalmellington and south of New Cumnock. Glen Afton runs deep into these hills. Ayrshire is one of the most agriculturally fertile regions of Scotland. Potatoes are grown in fields near the coast, using seaweed-based fertiliser, in addition the region produces pork products, other root vegetables, cattle. A number of small islands in the Firth of Clyde are part of Ayrshire, the chief of these being Horse Isle, Lady Isle and Ailsa Craig; the main rivers flowing to the Clyde coast are, from north to south, the following: The area that today forms Ayrshire was part of the area south of the Antonine Wall, occupied by the Romans during the reign of Emperor Antoninus Pius.

It was inhabited by the Damnonii. It formed part of the British Kingdom of Strathclyde, incorporated into the Kingdom of Scotland during the 11th century. In 1263, the Scots drove off the Norwegian leidang-army in a skirmish known as the Battle of Largs. A notable historic building in Ayrshire is Turnberry Castle, which dates from the 13th century or earlier, which may have been the birthplace of Robert the Bruce; the historic shire or sheriffdom of Ayr was divided into three districts or bailieries which made up the county of Ayrshire. The three districts were: Carrick in the south, it was situated between the Doon and the wild district of Galloway in the adjoining Stewartries, an area, little else than a vast tract of hills and mosses. Kyle in the centre, which included the royal burgh of Ayr, occupied the central district between the River Irvine in the north, the River Doon in the south and south-west, an area, quite hilly inland, it was subdivided into "Kyle Stewart", "King's Kyle," the former embracing the country between the Irvine and the River Ayr.

Cunninghame in the north which included the royal burgh of Irvine was that part of the county which lay north of the Irvine water, was in an area, level and fertile. The area used to be industrialised, with steel making, coal mining and in Kilmarnock numerous examples of production-line manufacturing, most famously Johnnie Walker whisky. In more recent history, Digital Equipment had a large manufacturing plant near Ayr from about 1976 until the company was taken over by Compaq in 1998; some supplier companies grew up to service this site and the more distant IBM plant at Greenock in Renfrewshire. Scotland's aviation industry has long been based in and around Prestwick and its international airport, although aircraft manufacture ceased at the former British Aerospace plant in 1998, a significant number of aviation companies are still based on the Prestwick site. However, unemployment in the region is above the national average. Throughout the 17th century, huge numbers of people from Ayrshire moved to Ulster, the northern province in Ireland, as part of the Plantation of Ulster, many of them with surnames such as Burns, Morrow, Flanagan and Cunningham.

Today, the Ulster Scots dialect is an offshoot of the version of Lowland Scots spoken in Ayrshire. The Ulster Scots dialect is still spoken throughout County Antrim and in parts of County Down and County Londonderry, as well as still being spoken in West Tír Eoghain and parts of County Donegal; the Local Government Act 1889 established a uniform system of county councils in Scotland and realigned the boundaries of many of Scotland's counties. Subsequently, Ayr county council was created in 1890. In 1930 the Local Government Act 1929 was implemented; this re-designated the Burghs into small burghs. This new categorisation influenced the level of autonomy that

Lorenzo Bellini, Italian physician and anatomist. He was born at Florence on the September 3, 1643. At the age of twenty, when he had begun his researches on the structure of the kidneys and had described the papillary ducts, as published in his book Exercitatio Anatomica de Structura Usu Renum, he was chosen professor of theoretical medicine at Pisa, but soon after was transferred to the chair of anatomy. After spending thirty years at Pisa, he was invited to Florence and appointed physician to the grand duke Cosimo III, was made senior consulting physician to Pope Clement XI, he died at Florence on the January 8, 1704. His works were published in a collected form at Venice in 1708. Attribution This article incorporates text from a publication now in the public domain: Chisholm, Hugh, ed.. "Bellini, Lorenzo". Encyclopædia Britannica. 3. Cambridge University Press. Fye, W B. "Lorenzo Bellini". Clinical Cardiology. 20: 181–182. Doi:10.1002/clc.4960200218. PMC 6656224. PMID 9034650. Klass, G M. "Bellini's concept of catarrh: an examination of a seventeenth-century iatromechanical viewpoint".

Clio medica. 9: 317–323. PMID 4141293. Lilien, O M. "Marcello Malpighi and Lorenzo Bellini". Investigative urology. 8: 698–699. PMID 4931080

Angelique is a Japanese media franchise based on the video game series. The series has only been released in Japan, with the exception of a Chinese PC version of the first game in the series, it is somewhat popular with overseas import gamers, who have started petitions in the hopes of English-translated releases of various games in the series. KOEI mentioned in an issue of Newtype USA; the basic lore of the series is built around a Queen who and wisely rules a Cosmos. By balancing elemental forces with the help of nine Guardians, she keeps the various planets in her domain stable and her people content. However, the powers of the Queen and the Guardians fade over time, successors must be appointed. In the first game and its various remakes, the protagonist is a 17-year-old girl named Angelique Limoges, chosen by the current Queen and her aide Dia as one of two candidates from the Royal Smallney Girls' Academy to become the next Queen, she is transported to the Flying City to begin her final examination.

Each of the candidates is given a land to populate. Whoever finishes populating their land first wins and becomes the next Queen, it is done with the help of nine Guardians who use their powers to make the people of the candidate's land happy, or to devastate their rival's lands. Along the way, the candidates can fall in love. If they choose love, they forfeit their chance to become Queen, but will live ever after; the story expands in titles, but most entries in the series feature one of a succession of girls named Angelique as the protagonist, with larger casts of characters. The roster of potential love interests swells to 19 characters in titles. Angelique Limoges Voiced by: Yuri Shiratori Angelique has the role of a Queen Candidate, is seventeen years old. Rosalia de Catargena Voiced by: Kotono Mitsuishi Another Queen Candidate, Rosalia is seventeen years old. Julious Voiced by: Shō Hayami Julious' role is the Guardian of Light, he is twenty-five years old and serves the queens. Clavis Voiced by: Kaneto Shiozawa, Hideyuki Tanaka Clavis has the role of Guardian of Dark, he is twenty-five years old.

Luva Voiced by: Toshihiko Seki Luva has the role of Guardian of Earth, he is twenty-six years old. Oscar Voiced by: Horiuchi Kenyuu Oscar's role is Guardian of Fire, he is twenty-two years old. Lumiale Voiced by: Nobuo Tobita Lumiale is twenty-one years old, has the role of Guardian of Water. Olivie Voiced by: Takehito Koyasu Olivie has the role of Guardian of Dream, he is twenty-two years old. Randy Voiced by: Nobutoshi Canna Randy is Eighteen years old, has the role of Guardian of WindZephel Voiced by: Mitsuo Iwata At seventeen years old, Zephel's role is Guardian of SteelMarcel Voiced by: Hiro Yuuki Marcel's role is Guardian of Green, he is fourteen years old. Angelique First installment in the series developed by Ruby Party; the game follows an ordinary high school girl, is chosen as a queen candidate. With help from the power of the nine Guardians, she aims to be the next Queen. Angelique is considered to have popularized the otome game market. Angelique Voice Fantasy, Angelique Special, Angelique Duet are all different versions of this game.

The game was released on September 1994 for Super Famicom. A Game Boy Advance version was released on March 21, 2003. Angelique Special is a revised version of the first game and features several new animated scenes, in addition to voice acting by several big-name voice actors. Among the new animated scenes were several love events that were not present in the original game. Others included the endings. Released on December 22, 1995 for PC-FX and published by published by NEC Home Electronics; the game was ported to PC, Sega Saturn, PlayStation on March 29, 1996. PlayStationAngelique Voice Fantasy included a special Audio CD and an add-on called Voicer-Kun, which allowed for the addition of voice acting; the game contents are otherwise identical to the original version. It was released on March 1996 for Super Famicom. Angelique Duet was released on July 1998 for Sega Saturn and PlayStation; the game was ported to the Nintendo DS on February 2006 This version allows the player to choose the usual heroine, Angelique Limoges, or her rival Rosalia de Catargena, as the main character.

The DS version introduced a messaging feature. Angelique Special 2 Second installment in the series. Angelique Collet, a girl who lives in the cosmos that the heroine of the first game now rules, is chosen as a queen candidate for a new cosmos; the count of male characters increases to include the nine Guardians, as well as three Tutors and three Collaborators. Angelique Trois Third installment in the series. Angelique Collet, now queen of a new cosmos, is drawn into a pocket cosmos, with the rest of the Angelique Special 2 cast, she develops the wilderness of Arcadia in order to free a strange being she finds there. Angelique Etoile Fourth installment in the series; the main character is a girl from the cosmos ruled by Angelique Limoges named Ange, who must save the cosmos as the "Legendary Etoile". Includes all of the major characters from previous Angelique titles, plus three new "Holy Beast Cosmos" Guardians. Neo Angelique A renewal of the series with all new characters. Angelique Tenkū no Requiem A traditional role-playing video game with dating sim events and multiple endings.

Angelique Collet is the heroine. The cosmos which Angelique Limoges rules is under attack from a mysterious figure called the "emperor", Angelique