Bacone College, formerly Bacone Indian University, is a private college in Muskogee, Oklahoma. Founded in 1880 as the Indian University by missionary Almon C. Bacone, it was originally affiliated with the mission arm of what is now American Baptist Churches USA. Renamed as Bacone College in the early 20th century, it is the oldest continuously operated institution of higher education in Oklahoma. The liberal arts college has had strong historic ties to several tribal nations, including the Muscogee and Cherokee. The Bacone College Historic District has been on the National Register of Historic Places listings in Muskogee County, Oklahoma since 2014.