Baitullah Mehsud was one of the founders and a leading member of the TTP in Waziristan, Pakistan, and the leader of the Tehrik-e-Taliban Pakistan (TTP). He formed the TTP from an alliance of about five militant groups in December 2007. He is thought by U.S. military analysts to have commanded up to 5,000 fighters and to have been behind numerous attacks in Pakistan including the assassination of Benazir Bhutto which he and others have denied.

The assassination of Benazir Bhutto took place on 27 December 2007 in Rawalpindi, Pakistan. Benazir Bhutto, the former Prime Minister of Pakistan and then-leader of the opposition party Pakistan People's Party, had been campaigning ahead of elections scheduled for January 2008. Shots were fired at her after a political rally at Liaqat National Bagh, and a suicide bomb was detonated immediately following the shooting. She was declared dead at 18:16 local time, at Rawalpindi General Hospital. Twenty-three other people were killed by the bombing. Bhutto had previously survived a similar attempt on her life that killed at least 180 people, after her return from exile two months earlier. Following the event, the Election Commission of Pakistan postponed the general elections by a month, which saw Bhutto's party win.