Baldwyn is a city located in Lee and Prentiss counties, Mississippi, located in the northern part of the Tupelo micropolitan area. The population was 3,071 at the 2020 census.

James Harrison "Babe" McCarthy, was an American professional and collegiate basketball coach. McCarthy was originally from Baldwyn, Mississippi. McCarthy may best be remembered for Mississippi State's appearance in the 1963 NCAA Men's Division I Basketball Tournament when his all-white team sneaked out of town in order to face Loyola University Chicago, which had four black starters.