The Bank of Saint George was a financial institution of the Republic of Genoa. It was founded in 1407 to consolidate the public debt, which had been escalating due to the war with Venice for trading and financial dominance. The Bank's primary mission was to facilitate the management of the San Giorgio shares (luoghi). It was one of the oldest chartered banks in Europe and of the world. The Bank's headquarters were at the Palazzo San Giorgio, which was built in the 13th century by the order of Guglielmo Boccanegra, uncle of Simone Boccanegra, the first Doge of Genoa.

The Republic of Genoa was a medieval and early modern maritime republic from the years 1099 to 1797 in Liguria on the northwestern Italian coast. During the Late Middle Ages, it was a major commercial power in both the Mediterranean Sea and the Black Sea. Between the 16th and 17th centuries, it was one of the major financial centers in Europe.