The Barker–Karpis Gang was one of the longest-lived criminal gangs during the Depression Era, spanning from 1931 to 1935. The gang was founded by Fred Barker and Alvin Karpis, and later joined by Fred's brother Arthur "Doc" Barker. Along with the three core members, the gang's network spanned up to 25 members at one point.

Frederick George Barker was an American criminal who, along with Alvin Karpis, co-founded the Barker-Karpis gang, which committed numerous robberies, murders and kidnappings during the 1930s. Barker was the youngest son of Ma Barker, all of whose children were criminals. He was killed in a lengthy gunfight with the Federal Bureau of Investigation (FBI) in 1935.