Baron Sandys is a title that has been created three times, once in the Peerage of England, once in the Peerage of Great Britain and once in the Peerage of the United Kingdom.

William Sandys, 1st Baron Sandys, KG, of The Vyne in the parish of Sherborne St John, Hampshire, was an English diplomat, and a favourite of King Henry VIII, whom he served as Lord Chamberlain. In the 1520s he built a palatial Tudor-style mansion at "The Vyne", which survives in a reduced and classicised form as a possession of the National Trust.