Barry Bonds

Barry Lamar Bonds is an American former professional baseball left fielder who played 22 seasons in Major League Baseball with the Pittsburgh Pirates and San Francisco Giants. He received a record seven NL MVP awards, eight Gold Glove awards, a record 12 Silver Slugger awards, 14 All-Star selections, he is considered to be one of the greatest baseball players of all time. Bonds was regarded as an exceptional hitter: he led MLB in on-base plus slugging six times, placed within the top five hitters in 12 of his 17 qualifying seasons, he holds many MLB hitting records, including most career home runs, most home runs in a single season and most career walks. Bonds was known as a talented all-around baseball player, he won eight Gold Glove awards for his defensive play in the outfield. He stole 514 bases with his baserunning speed, becoming the first and only MLB player to date with at least 500 home runs and 500 stolen bases, he is ranked second in career Wins Above Replacement among all major league position players by both Fangraphs and, behind only Babe Ruth.

However, Bonds led a controversial career, notably as a central figure in baseball's steroids scandal. In 2007, he was indicted on charges of perjury and obstruction of justice for lying to the grand jury during the federal government's investigation of BALCO; the perjury charges against Bonds were dropped and an initial obstruction of justice conviction was overturned in 2015. Bonds became eligible for the National Baseball Hall of Fame in 2013. Bonds was born in Riverside, California to Patricia and former major leaguer Bobby Bonds, grew up in San Carlos and attended Junípero Serra High School in San Mateo, where he excelled in baseball and football, he played on the junior varsity team during his freshman year and the remainder of his high school career on the varsity team. He garnered a.467 batting average his senior year, was named prep All-American. The Giants drafted Bonds in the second round of the 1982 MLB draft as a high school senior, but the Giants and Bonds were unable to agree on contract terms when Tom Haller's maximum offer was $70,000 and Bonds’ minimum to go pro was $75,000, so Bonds instead decided to attend college.

Bonds attended Arizona State University, hitting.347 with 175 runs batted in. In 1984 he had 30 stolen bases. In 1985, he hit 23 home runs with a. 368 batting average. He was a Sporting News All-American selection that year, he tied the NCAA record with seven consecutive hits in the College World Series as sophomore and was named to All-Time College World Series Team in 1996. Bonds was not well liked by his Sun Devil teammates, in part because in the words of longtime coach Jim Brock, he was "rude and self-centered." For instance, when he was suspended for breaking curfew, the other players voted against his return though he was the best player on the team. He graduated from Arizona State in 1986 with a degree in criminology, he was named ASU On Deck Circle Most Valuable Player. During college, he played part of one summer in the amateur Alaska Baseball League with the Alaska Goldpanners; the Pittsburgh Pirates drafted Bonds as the sixth overall pick of the 1985 Major League Baseball draft. He joined the Prince William Pirates of the Carolina League and was named July 1985 Player of the Month for the league.

In 1986, he hit.311 in 44 games for the Hawaii Islanders of the Pacific Coast League. Before Bonds made it to the major leagues in Pittsburgh, Pirate fan attendance was low, with 1984 and 1985 attendance below 10,000 per game for the 81-game home schedule. Bonds made his major league debut on May 30, 1986. In 1986, Bonds led National League rookies with 16 home runs, 48 RBI, 36 stolen bases and 65 walks, but he finished 6th in Rookie of the Year voting, he played center field in 1986, but switched to left field with the arrival of centerfielder Andy Van Slyke in 1987. In his early years, Bonds batted as the leadoff hitter. With Van Slyke in the outfield, the Pirates had a venerable defensive tandem that worked together to cover a lot of ground on the field although they were not close off the field; the Pirates experienced a surge in fan enthusiasm with Bonds on the team and set the club attendance record of 52,119 in the 1987 home opener. That year, he hit 25 home runs in his second season, along with 59 RBIs.

Bonds improved in 1988. The Pirates broke. Bonds now fit into a respected lineup featuring Bobby Bonilla, Van Slyke and Jay Bell, he finished with 19 homers, 58 RBIs, 14 outfield assists in 1989, second in the NL. Following the season, rumors that he would be traded to the Los Angeles Dodgers for Jeff Hamilton and John Wetteland, but the team denied the rumors and no such trade occurred. Bonds won his first MVP Award in 1990, hitting.301 with 114 RBIs. He stole 52 bases, which were third in the league, to become a first-time member of the 30–30 club, he won his first Gold Glove Silver Slugger Award. That year, the Pirates won the National League East title for their first postseason berth since winning the 1979 World Series. However, the Cincinnati Reds, whose last post-season berth had been in 1979 when they lost to the Pirates in that year's NLCS defeated the Pirates in the NL

Denintuzumab mafodotin

Denintuzumab mafodotin is a humanized monoclonal antibody-drug conjugate designed for the treatment of CD19-positive acute lymphoblastic leukemia and B-cell non-Hodgkin lymphoma. It consists of an anti-CD19 mAb linked to a cytotoxic agent; this drug was developed by Seattle Genetics. Denintuzumab refers to the anti-CD19 antibody, mafodotin refers to MMAF and the chemical linkage; the drug is in phase I clinical trials. Preliminary phase I results for B-cell malignancies, including diffuse large B-cell lymphoma and B-lineage acute lymphocytic leukemia are being presented at the ASH medical conference Dec 2015. A separate randomized phase 2 trial started in 2015 to evaluate SGN-CD19A in combination with R-ICE chemotherapy for second-line DLBCL. A phase 2 clinical trial in front-line DLBCL is started in 2016. Both trials were terminated by the Sponsor based on portfolio prioritization

Touching (Paul Bley album)

Touching is the sixth album led by jazz pianist Paul Bley featuring tracks recorded in Copenhagen in 1965 and released on the Danish Fontana label. Allmusic awarded the album 3 stars stating "Although not all that memorable, the playing by the trio is at a high level and it is interesting to hear Paul Bley's mid-'60s avant-garde improvising style which offered a contrast to the more dense playing of Cecil Taylor"; the Penguin Guide to Jazz said "The playing was superb... Carter and Altschul offer solid support but the focus is on the piano". Paul Bley - piano Kent Carter - bass Barry Altschul - drums