Bartholomew County is a county located in the U.S. state of Indiana. The population was 82,208 at the 2020 census. The county seat is Columbus. The county was determined by the U.S. Census Bureau to be home to the mean center of U.S. population in 1900.

Columbus is a city in, and the county seat of, Bartholomew County, Indiana, United States. The population was 50,474 at the 2020 Census. The city is known for its architectural significance, having commissioned numerous noted works of modern architecture and public art since the mid-20th century; the annual program Exhibit Columbus celebrates this legacy. Located about 40 mi (64 km) south of Indianapolis, on the east fork of the White River, it is the state's 20th-largest city. It is the principal city of the Columbus, Indiana metropolitan statistical area, which encompasses all of Bartholomew County. Columbus is the birthplace of former Indiana Governor and former Vice President of the United States, Mike Pence.