The Church of the Annunciation, sometimes also referred to as the Basilica of the Annunciation, is a Catholic church in Nazareth, in northern Israel. It is one of two claimants to the site of the Annunciation – in which angel Gabriel appeared to the Virgin Mary and announced that she would give birth to Jesus – the other being the Greek Orthodox Church of the Annunciation.

Nazareth is the largest city in the Northern District of Israel. In 2022 its population was 78,007. Known as "the Arab capital of Israel", Nazareth serves as a cultural, political, religious, economic and commercial center for the Arab citizens of Israel, as well as a center of Arab and Palestinian nationalism. The inhabitants are predominantly Arab citizens of Israel, of whom 69% are Muslim and 30.9% Christian. The city also commands immense religious significance, deriving from its status as the hometown of Jesus, the central figure of Christianity and a prophet in Islam.