The Battle of Cape Girardeau was a military demonstration of the American Civil War, occurring on April 26, 1863 in Cape Girardeau, Missouri. The conflict was part of the pursuit of US Brigadier General John McNeil through Southeast Missouri by Confederate Brigadier General John S. Marmaduke. Though the conflict to this day is known as a battle, it was a relatively small engagement whose primary importance was as the turning point that brought General Marmaduke's second Missouri raid to an end.

Cape Girardeau is a city in Cape Girardeau and Scott Counties in the U.S. state of Missouri. At the 2020 census, the population was 39,540. The city is one of two principal cities of the Cape Girardeau, MO-IL Metropolitan Statistical Area, which encompasses Alexander County, Illinois, Bollinger County, Missouri and Cape Girardeau County, Missouri and has a population of 97,517. The sliver of the city located in Scott County is part of the Sikeston Micropolitan Statistical Area, and the entire city forms the core of the Cape Girardeau-Sikeston Combined Statistical Area.