The Battle of La Guaira or La Guayra, took place on 2 March 1743 in the Caribbean, off the coast of La Guaira, present day Venezuela. La Guaira was a port of the Royal Gipuzkoan Company of Caracas, whose ships had rendered great assistance to the Spanish navy during War of Jenkins' Ear in carrying troops, arms, stores and ammunition from Spain to her colonies, and its destruction would be a severe blow both to the Company and the Spanish Government. A British expeditionary fleet under Sir Charles Knowles was defeated, and the expedition ended in failure. 600 men were killed, among whom was the captain of HMS Burford, and many of the ships were badly damaged or lost. Knowles was therefore unable to proceed to Puerto Cabello until he had refitted.

HMS Suffolk was a 70-gun third-rate ship of the line of the Royal Navy, built by contract of 20 February 1678 by Sir Henry Johnson at Blackwall. She participated in the War of the English Succession 1689 - 1697, in the Battles of Beachy Head and Barfleur. She was rebuilt in 1699. She was actively involved in the War of Spanish Succession 1702 - 1713. Her later career was as guard ship duties, deployments to the Baltic Sea and the West Indies. She was finally broken in 1765 after lying in Ordinary for almost twenty years.