The Battle of Nablus took place, together with the Battle of Sharon during the set piece Battle of Megiddo between 19 and 25 September 1918 in the last months of the Sinai and Palestine Campaign of the First World War. Fighting took place in the Judean Hills where the British Empire's XX Corps attacked the Ottoman Empire's Yildirim Army Group's Seventh Army defending their line in front of Nablus. This battle was also fought on the right flank in the Jordan Valley, where Chaytor's Force attacked and captured the Jordan River crossings, before attacking the Fourth Army at Es Salt and Amman capturing many thousands of prisoners and extensive territory. The Battle of Nablus began half a day after the main Battle of Sharon, which was fought on the Mediterranean section of the front line where the XXI Corps attacked the Eighth Army defending the line in front of Tulkarm and Tabsor and the Desert Mounted Corps which rode north to capture the Esdrealon Plain. Together these two battles, known as the Battle of Megiddo, began the Final Offensive of the war in the Sinai and Palestine campaign.

The Battle of Sharon fought between 19 and 25 September 1918, began the set piece Battle of Megiddo half a day before the Battle of Nablus, in which large formations engaged and responded to movements by the opposition, according to pre-existing plans, in the last months of the Sinai and Palestine Campaign of World War I. The fighting took place over a wide area from the Mediterranean Sea east to the Rafat salient in the Judean Hills. Here the Egyptian Expeditionary Force (EEF) XXI Corps with the French brigade sized Détachement Français de Palestine et de Syrie attacked the Yildirim Army Group Eighth Army's XXII Corps and German Asia Corps. The Battle of Sharon extended well behind the Ottoman front lines when the Desert Mounted Corps rode through a gap in the front line across the Plain of Sharon to occupy the Esdraelon Plain. Meanwhile, during the Battle of Nablus the XX Corps attacked Nablus while Chaytor's Force held the right flank in the Jordan Valley before advancing to secure bridges and fords across the Jordan River, to continue the encirclement the defenders in the Judean Hills. Subsequently, Chaytor's Force advanced against the Fourth Army to capture Es Salt and Amman after the Second Battle of Amman.