The Battle of Nablus took place, together with the Battle of Sharon during the set piece Battle of Megiddo between 19 and 25 September 1918 in the last months of the Sinai and Palestine Campaign of the First World War. Fighting took place in the Judean Hills where the British Empire's XX Corps attacked the Ottoman Empire's Yildirim Army Group's Seventh Army defending their line in front of Nablus. This battle was also fought on the right flank in the Jordan Valley, where Chaytor's Force attacked and captured the Jordan River crossings, before attacking the Fourth Army at Es Salt and Amman capturing many thousands of prisoners and extensive territory. The Battle of Nablus began half a day after the main Battle of Sharon, which was fought on the Mediterranean section of the front line where the XXI Corps attacked the Eighth Army defending the line in front of Tulkarm and Tabsor and the Desert Mounted Corps which rode north to capture the Esdrealon Plain. Together these two battles, known as the Battle of Megiddo, began the Final Offensive of the war in the Sinai and Palestine campaign.

Chaytor's Force named after its commander, Major General Edward Chaytor, was a composite division-sized force which served in the British Egyptian Expeditionary Force during the Sinai and Palestine Campaign of the First World War. The force of 11,000 men, consisted of a division headquarters, three mounted and one infantry brigades, four independent infantry battalions and four artillery batteries and was detached from the Desert Mounted Corps for deception operations.