The Battle of Panium was fought in 200 BC near Paneas between Seleucid and Ptolemaic forces as part of the Fifth Syrian War. The Seleucids were led by Antiochus III the Great, while the Ptolemaic army was led by Scopas of Aetolia. The Seleucids achieved a complete victory, annihilating the Ptolemaic army and conquering the province of Coele-Syria. The Ptolemaic Kingdom never recovered from its defeat at Panium and ceased to be an independent great power. Antiochus secured his southern flank and began to concentrate on the looming conflict with the Roman Republic.

Coele-Syria was a region of Syria in classical antiquity. The term originally referred to the "hollow" Beqaa Valley between the Lebanon and the Anti-Lebanon mountain ranges, but sometimes it was applied to a broader area of the region of Syria. The area is now part of modern-day Syria and Lebanon.