The Battle of Pydna took place in 168 BC between Rome and Macedon during the Third Macedonian War. The battle saw the further ascendancy of Rome in the Hellenistic world and the end of the Antigonid line of kings, whose power traced back to Alexander the Great. The battle is also considered to be a victory of the Roman legion's manipular system's flexibility over the Macedonian phalanx's rigidity.

The Antigonid dynasty was a Macedonian Greek royal house which ruled the kingdom of Macedon during the Hellenistic period. Founded by Antigonus I Monophthalmus, a general and successor of Alexander the Great, the dynasty first came to power after the Battle of Salamis in 306 BC and ruled much of Hellenistic Greece from 294 until their defeat at the Battle of Pydna in 168 BC, after which Macedon came under the control of the Roman Republic.