Beatrice d'Este was Duchess of Bari and Milan by marriage to Ludovico Sforza. She was one of the most important personalities of the time and, despite her short life, she was a major player in Italian politics. A woman of culture, an important patron, a leader in fashion: alongside her illustrious husband she made Milan one of the greatest capitals of the European Renaissance. With her own determination and bellicose nature, she was the soul of the Milanese resistance against the enemy French during the first of the Italian Wars, when her intervention was able to repel the threats of the Duke of Orléans, who was on the verge of conquering Milan.

The First Italian War, or Charles VIII's Italian War, was the opening phase of the Italian Wars. The war pitted Charles VIII of France, who had initial Milanese aid, against the Holy Roman Empire, Spain and an alliance of Italian powers led by Pope Alexander VI, known as the League of Venice.