Beatriz Enríquez de Arana (1465–1521?) was the mistress of Christopher Columbus and mother of Ferdinand Columbus, Columbus's younger son.

Christopher Columbus was an Italian explorer and navigator from the Republic of Genoa who completed four Spanish-based voyages across the Atlantic Ocean sponsored by the Catholic Monarchs, opening the way for the widespread European exploration and European colonization of the Americas. His expeditions were the first known European contact with the Caribbean and Central and South America.