Bellator 255: Pitbull vs. Sanchez 2 was a mixed martial arts event produced by Bellator MMA that took place on April 2, 2021 at Mohegan Sun Arena in Uncasville, Connecticut. The event was Bellator's first of the year following a four-month break after Bellator 254.

Matt Mitrione is an American retired mixed martial artist and former American football player, who competed for both the Ultimate Fighting Championship (UFC), and most recently for Bellator MMA. Prior to embarking on an MMA career, Mitrione played college football at Purdue University, and he turned pro and played in the National Football League (NFL) with the New York Giants and the Minnesota Vikings. He was a featured fighter on The Ultimate Fighter: Heavyweights.