Ruth Isabelle Skinner was an American businesswoman and philanthropist. She was a daughter of silk manufacturer William Skinner (1824–1902) and his second wife, the former Sarah Elizabeth Allen (1834–1908). Belle Skinner was a humanitarian and music-lover whose life her brother William memorialized in the construction of the Skinner Hall of Music at Vassar College in 1932. She lived most of her life at the family home, Wistariahurst, in Holyoke, Massachusetts, now a historic site. She renovated and expanded this house to reflect her interests, including adding the music room, where she housed her musical instrument collection, now housed at Yale University.

Wistariahurst is a historic house museum and the former estate of the Skinner family, located at 238 Cabot Street in Holyoke, Massachusetts. It was built in 1868 for William Skinner, the owner of a successful silk spinning and textile business, and is named for the abundant wisteria vines which cascade across its eastern facade. Originally constructed in Williamsburg in 1868, the mansion designed by Northampton architect William Ferro Pratt was moved to Holyoke in 1874, following the devastating flood which swept away the original Skinner mills. Following the death of Belle Skinner, its music room was operated as a private museum from 1930 to 1959, housing the Belle Skinner Collection of Old Musical Instruments, before their donation by the family to Yale University. Since 1959 it has been operated as the Wistariahurst Museum, and is open to the public. The property was listed on the National Register of Historic Places in 1973.