Berkeley Plantation, one of the first plantations in America, comprises about 1,000 acres (400 ha) on the banks of the James River on State Route 5 in Charles City County, Virginia. Berkeley Plantation was originally called Berkeley Hundred, named after the Berkeley Company of England. In 1726, it became the home of the Harrison family of Virginia, after Benjamin Harrison IV located there and built one of the first three-story brick mansions in Virginia. It is the ancestral home of two presidents of the United States: William Henry Harrison, who was born there in 1773 and his grandson Benjamin Harrison. It is now a museum property, open to the public.

Virginia State Route 5 is a primary state highway in the Commonwealth of Virginia. It runs between the independent cities of Richmond and Williamsburg. Between Charles City County and James City County, it crosses the Chickahominy River via the Judith Stewart Dresser Bridge, a fixed-span bridge which replaced historic Barrett's Ferry and the former drawbridge.