The Berlin Northern Railway is a 223-kilometre-long main line route, that runs from Berlin via Neustrelitz and Neubrandenburg to Stralsund on the Baltic Sea coast. Nowadays, long-distance and regional traffic on the Nordbahn is routed at Hohen Neuendorf onto the Berlin Outer Ring to the Karower Kreuz and on to Berlin Main Station or Berlin-Lichtenberg.

Stralsund, officially the Hanseatic City of Stralsund, is the fifth-largest city in the northeastern German federal state of Mecklenburg-Western Pomerania after Rostock, Schwerin, Neubrandenburg and Greifswald, and the second-largest city in the Pomeranian part of the state. It is located on the southern coast of the Strelasund, a sound of the Baltic Sea separating the island of Rügen from the Pomeranian mainland.