Berwick is a borough in Columbia County, Pennsylvania, United States. It is part of Northeastern Pennsylvania and is located 28 miles (45 km) southwest of Wilkes-Barre. As of the 2020 census, Berwick had a population of 10,355. It is one of the two principal communities of the Bloomsburg–Berwick metropolitan area, which covers Columbia and Montour counties, and had a combined population of 85,562 at the 2010 census.