The Best Female Athlete with a Disability ESPY Award is an annual award honoring the achievements of a female individual from the community of disabled sports. Established with the aid of disability advocate and former United States Paralympic soccer player Eli Wolff, the accolade's trophy, designed by sculptor Lawrence Nowlan, is presented to the disabled sportswomen adjudged to be the best at the annual ESPY Awards ceremony in Los Angeles. The Best Female Athlete with a Disability ESPY Award was first bestowed as part of the ESPY Awards in 2005 after the non-gender specific Best Athlete with a Disability ESPY Award was presented the previous three years. Balloting for the award is undertaken by fans over the Internet from between three and five choices selected by the ESPN Select Nominating Committee, which is composed of a panel of experts. It is conferred in July to reflect performance and achievement over the preceding twelve months.

Jessica Tatiana Long is a Russian-American Paralympic swimmer from Baltimore, Maryland, who competes in the S8, SB7 and SM8 category events. She has held many world records and competed at five Paralympic Games, winning 29 medals. She has won over 50 world championship medals.