Bethune is a small town in Kershaw County, South Carolina, United States. The population was 334 at the 2010 census. It is part of the Columbia, South Carolina Metropolitan Statistical Area.

Kershaw County is a county located in the U.S. state of South Carolina. As of the 2020 census, its population was 65,403. The county seat and largest community is Camden. The county was created in 1791 from parts of Claremont, Lancaster, Fairfield, and Richland counties. It is named for Col. Joseph Kershaw (1727–1791), an early settler and American Revolutionary War patriot.