The Bhusawal–Kalyan section is part of the Howrah–Nagpur–Mumbai line and Howrah–Prayagraj–Mumbai line. It connects Bhusawal and Kalyan both in the Indian state of Maharashtra. One of the branch lines, Jalgaon–Surat line, runs partly in Gujarat.

The Howrah–Prayagraj–Mumbai line, is a railway line connecting Kolkata and Mumbai via Prayagraj. The 2,160-kilometre long (1,340 mi) railway line was opened to traffic in 1870. This railway line was 2,146-kilometre long (1,333 mi) until 2004. In 2004 the construction of Indira Sagar Dam submerged the old alignment near Khandwa & a new alignment of 14-kilometre long (8.7 mi) was relaid.