Bi-fuel vehicles are vehicles with multifuel engines capable of running on two fuels. The two fuels are stored in separate tanks and the engine is able to run on one fuel at a time. On internal combustion engines, a bi-fuel engine typically burns gasoline and a volatile alternate fuel such as natural gas (CNG), LPG, or hydrogen. Bi-fuel vehicles have the capability to switch back and forth from the gasoline to the other fuel, manually or automatically. A related concept is the duel-fuel vehicle which must burn both fuels in combination. Diesel engines converted to use gaseous fuels fall into this class due to the different ignition system.

Multifuel, sometimes spelled multi-fuel, is any type of engine, boiler, or heater or other fuel-burning device which is designed to burn multiple types of fuels in its operation. One common application of multifuel technology is in military settings, where the normally-used diesel or gas turbine fuel might not be available during combat operations for vehicles or heating units. Multifuel engines and boilers have a long history, but the growing need to establish fuel sources other than petroleum for transportation, heating, and other uses has led to increased development of multifuel technology for non-military use as well, leading to many flexible-fuel vehicle designs in recent decades.