Big Nate Strikes Again is a realistic fiction novel by American cartoonist Lincoln Peirce. It is based on the comic strip and the second book in the Big Nate novel series. The book was released on October 19, 2010. It is aimed at children aged 8 to 12. It was published by HarperCollins Publishers. The book has a 13,928 sale rank.

Lincoln Peirce is an American cartoonist and animator, best known as the creator of the successful Big Nate comic strip and as the author/illustrator of a series of Big Nate novels for young readers. He has also written a number of animated shorts that have appeared on Cartoon Network and Nickelodeon. Peirce is the creator of the animated series based on his aforementioned book and comic strip series. The series premiered on the Paramount+ streaming service.