Big Stone Gap is a town in Wise County, Virginia, United States. The town was economically centered around the coal industry for much of its early development. The population was 5,254 at the 2020 census.

Wise County is a county located in the U.S. state of Virginia. The county was formed in 1856 from Lee, Scott, and Russell Counties and named for Henry A. Wise, who was the Governor of Virginia at the time. The county seat is in Wise.