In Africa, the Big five game animals are the lion, leopard, rhinoceros, elephant, and African buffalo. The term was coined by big-game hunters to refer to the five most difficult animals in Africa to hunt on foot, but is now more widely used by game viewing tourists and safari tour operators. They are examples of charismatic megafauna, featuring prominently in popular culture, and are among the most famous of Africa's large animals.

A safari is an overland journey to observe wild animals, especially in Southeast Africa. The so-called "Big Five" game animals of Africa – lion, leopard, rhinoceros, elephant, and Cape buffalo – particularly form an important part of the safari market, both for wildlife viewing and big-game hunting.