Binondo Church, formally known as the Minor Basilica and National Shrine of Saint Lorenzo Ruiz and also as Our Lady of the Most Holy Rosary Parish, is located in the district of Binondo, Manila fronting Plaza San Lorenzo Ruiz, in the Philippines. This church was founded by Dominican priests in 1596 to serve their Chinese converts to Christianity. The original building was destroyed in 1762 by British bombardment. A new granite church was completed on the same site in 1852 however it was greatly damaged during the Second World War, with only the western façade and the octagonal belfry surviving.

Lorenzo Ruiz, also called Saint Lorenzo of Manila, is a Filipino saint venerated in the Catholic Church. A Chinese Filipino, he became his country's protomartyr after his execution in Japan by the Tokugawa Shogunate during its persecution of Japanese Christians in the 17th century.