A biodiversity reserve of Quebec is a protected area established to promote maintenance of biodiversity in the terrestrial environment and more specifically to maintain representatives of the various natural regions of Quebec, Canada. There are five biodiversity reserves in Quebec with permanent protection status.

The Uapishka Biodiversity Reserve is a protected area in the Côte-Nord region of Quebec. It is one of five biodiversity reserves in the province. It is to the east of the Manicouagan Reservoir and includes a large part of the Monts Groulx. It is also part of the central area of the Manicouagan Uapishka Biosphere Reserve.