Biomarker
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In biomedical contexts, a biomarker, or biological marker, is a measurable indicator of some biological state or condition. Biomarkers are often measured and evaluated using blood, urine, or soft tiss
After a heart attack, a number of different cardiac biomarkers can be measured to determine exactly when an attack occurred and how severe it was.
The epidermal growth factor receptor is a transmembrane protein that is a receptor for members of the epidermal growth factor family of extracellular protein ligands.
Biomarker
…and HER2/neu in breast cancer, the Philadelphia chromosome in chronic myelogenous leukemia, c-KIT mutations in gastrointestinal stromal tumors and epidermal growth factor receptor mutations in non-small-cell lung cancer. Diagnostic biomarkers that meet a burden of proof can serve a role in narrowing down diagnosis. This can lead…
Diagram of the EGF receptor highlighting important domains
1ivo: Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.
1m14: Tyrosine Kinase Domain from Epidermal Growth Factor Receptor
1m17: Epidermal Growth Factor Receptor tyrosine kinase domain with 4-anilinoquinazoline inhibitor erlotinib