Biscoe is a town in Montgomery County, North Carolina, United States. The population was 1,700 at the 2010 census. The town is named after Henry Biscoe, an important customer of the local lumber business.

Montgomery County is a rural county located in the southern Piedmont of the U.S. state of North Carolina. As of the 2020 census, the population was 25,751. Its county seat is Troy.