Bishop Luers High School is a small Catholic high school located in the southside of Fort Wayne, Indiana, United States. Bishop Luers is owned and operated by the Roman Catholic Diocese of Fort Wayne-South Bend. The school was founded in 1958 by the Franciscan Fathers of the Saint John the Baptist Province in Cincinnati, Ohio, along with the Sisters of Saint Francis Province in Mishawaka, Indiana. The first bishop of the diocese, John Henry Luers, is the namesake of the school.

The Diocese of Fort Wayne–South Bend is a Latin Church ecclesiastical territory, or diocese, of the Catholic Church in north-central and northeastern Indiana in the United States.