The Bishopric of Merseburg was an episcopal see on the eastern border of the medieval Duchy of Saxony with its centre in Merseburg, where Merseburg Cathedral was constructed. The see was founded in 967 by Emperor Otto I at the same time in the same manner as those of Meissen and Zeitz, all suffragan dioceses of the Archbishopric of Magdeburg as part of a plan to bind the adjacent Slavic ("Wendish") lands in the Saxon Eastern March beyond the Saale River more closely to the Holy Roman Empire.

Merseburg is a town in central Germany in southern Saxony-Anhalt, situated on the river Saale, and approximately 14 km south of Halle (Saale) and 30 km west of Leipzig. It is the capital of the Saalekreis district. It had a diocese founded by Archbishop Adalbert of Magdeburg. The University of Merseburg is located within the town. Merseburg has around 35,000 inhabitants.