Blacksburg is a small town in Cherokee County, South Carolina, United States. The population was 1,848 at the 2010 census. The communities of Antioch, Cherokee Falls, Kings Creek, Cashion Crossroads, Buffalo, and Mount Paran are located near the town.

The Upstate, historically known as the Upcountry, is a region of the U.S. state of South Carolina, comprising the northwesternmost area of the state. Although loosely defined among locals, the general definition includes the 10 counties of the commerce-rich I-85 corridor in the northwest corner of South Carolina. This definition coincided with the Greenville-Spartanburg-Anderson, SC Combined Statistical Area, as first defined by the Office of Management and Budget (OMB) in 2015. In 2023, the OMB issued its most updated definition of the CSA that coincides again with the 10-county region.