Bless Me, Ultima is a coming-of-age novel by Rudolfo Anaya centering on Antonio Márez y Luna and his mentorship under his curandera and protector, Ultima. It has become the most widely read and critically acclaimed novel in the New Mexican literature canon since its first publication in 1972. Teachers across disciplines in middle schools, high schools and universities have adopted it as a way to implement multicultural literature in their classes. The novel reflects Hispano culture of the 1940s in rural New Mexico. Anaya's use of Spanish, mystical depiction of the New Mexican landscape, use of cultural motifs such as La Llorona, and recounting of curandera folkways such as the gathering of medicinal herbs, gives readers a sense of the influence of indigenous cultural ways that are both authentic and distinct from the mainstream.

Rudolfo Anaya was an American author. Noted for his 1972 novel Bless Me, Ultima, Anaya was considered one of the founders of the canon of contemporary Chicano and New Mexican literature. The themes and cultural references of the novel, which were uncommon at the time of its publication, had a lasting impression on fellow Latino writers. It was subsequently adapted into a film and an opera.