Blombos Cave is an archaeological site located in Blombos Private Nature Reserve, about 300 km east of Cape Town on the Southern Cape coastline, South Africa. The cave contains Middle Stone Age (MSA) deposits currently dated at between c. 100,000 and 70,000 years Before Present (BP), and a Late Stone Age sequence dated at between 2000 and 300 years BP. The cave site was first excavated in 1991 and field work has been conducted there on a regular basis since 1997, and is ongoing.

The Middle Stone Age was a period of African prehistory between the Early Stone Age and the Late Stone Age. It is generally considered to have begun around 280,000 years ago and ended around 50–25,000 years ago. The beginnings of particular MSA stone tools have their origins as far back as 550–500,000 years ago and as such some researchers consider this to be the beginnings of the MSA. The MSA is often mistakenly understood to be synonymous with the Middle Paleolithic of Europe, especially due to their roughly contemporaneous time span; however, the Middle Paleolithic of Europe represents an entirely different hominin population, Homo neanderthalensis, than the MSA of Africa, which did not have Neanderthal populations. Additionally, current archaeological research in Africa has yielded much evidence to suggest that modern human behavior and cognition was beginning to develop much earlier in Africa during the MSA than it was in Europe during the Middle Paleolithic. The MSA is associated with both anatomically modern humans as well as archaic Homo sapiens, sometimes referred to as Homo helmei. Early physical evidence comes from the Gademotta Formation in Ethiopia, the Kapthurin Formation in Kenya and Kathu Pan in South Africa.