BloodRayne is a media franchise that originated with an action-adventure video game series originally developed by Terminal Reality and published by Majesco Entertainment which began with the game of the same name in 2002.

Rayne, sometimes called Agent BloodRayne or simply the Dhampir, is a fictional character in the BloodRayne series of video games. Created by Terminal Reality, she is the series' titular protagonist, appearing in both games and later extended media, such as comic books and films related to the series. In English she is voiced by Laura Bailey in BloodRayne and BloodRayne 2 and Jessie Seely in BloodRayne: Betrayal; in Japanese she is voiced by Romi Park in BloodRayne. She was portrayed by Kristanna Loken in the first live action film, and by Natassia Malthe for its sequels.