The Bois Brule Bottom is an alluvial floodplain in Bois Brule Township in Perry County, Missouri stretching between Bois Brule Creek to the west and the Mississippi River to the east.

Perry County is a county located in the southeastern portion of the U.S. state of Missouri. As of the 2020 census, the population was 18,956. Its county seat is Perryville. The county was officially organized on November 16, 1820 from Ste. Genevieve County and was named after Oliver Hazard Perry, a naval hero of the War of 1812.