Bolton Hill is a neighborhood in Baltimore, Maryland, with 20 blocks of mostly preserved buildings from the late 19th century. It is listed on the National Register of Historic Places, preserved as a Baltimore City Historic District, and included within the boundaries of Baltimore National Heritage Area. The neighborhood is bounded by North Avenue, Mount Royal Avenue, Cathedral Street, Dolphin Street, and Eutaw Place. Bolton Hill is a largely residential neighborhood with three-story row houses with red brick, white marble steps, and high ceilings. There are also larger more ornate originally single-family houses, many houses of worship, parks, monuments, and a few large apartment buildings. Many significant residents have lived in the neighborhood, including F. Scott Fitzgerald, Woodrow Wilson, the Cone sisters, and Florence Rena Sabin.

Claribel Cone (1864–1929) and Etta Cone (1870–1949), collectively known as the Cone sisters, were active as American art collectors, world travelers, and socialites during the first part of the 20th century. Claribel trained as a physician and Etta as a pianist. Their social circle included Henri Matisse, Pablo Picasso and Gertrude Stein. They gathered one of the best known private collections of modern art in the United States at their Baltimore apartments, and the collection now makes up a wing of the Baltimore Museum of Art. Their collection was estimated to be worth almost a billion US dollars in 2002.