Bonne Terre is a city in St. Francois County, Missouri, United States with a population of 6,864 at the 2010 census. Situated in the Southeast Missouri Lead District, lead mining shaped the history and character of the area from the earliest French settlers in the 1720s until today, even though Bonne Terre Mine established by St. Joseph lead mining company in 1864 closed in 1962. Mine tailing piles eroded, and contaminated the area as dust, posing residential hazards or were washed into the Big River. Only in 1992, the Bonne Terre Mine Tailings Site was listed as a Superfund site; as of 2022 remediation is still ongoing.

St. Francois County is a county in the Lead Belt region in the U.S. state of Missouri. At the 2020 census, the population was 66,922. The largest city and county seat is Farmington. The county was officially organized on December 19, 1821. It was named after the St. Francis River. The origin of the river's name is unclear. It may refer to St. Francis of Assisi. Another possibility is that Jacques Marquette, a Jesuit who explored the region in 1673, named the river for the Jesuit missionary Francis Xavier; Marquette had spent some time at the mission of St. François Xavier before his voyage and, as a Jesuit, was unlikely to have given the river a name honoring the Franciscans.