The Book of Cerne is an early ninth-century Insular or Anglo-Saxon Latin personal prayer book with Old English components. It belongs to a group of four such early prayer books, the others being the Royal Prayerbook, the Harleian prayerbook, and the Book of Nunnaminster. It is now commonly believed to have been produced sometime between ca. 820 and 840 AD in the Southumbrian/Mercian region of England. The original book contains a collection of several different texts, including New Testament Gospel excerpts, a selection of prayers and hymns with a version of the Lorica of Laidcenn, an abbreviated or Breviate Psalter, and a text of the Harrowing of Hell liturgical drama, which were combined to provide a source used for private devotion and contemplation. Based on stylistic and palaeographical features, the Book of Cerne has been included within the Canterbury or Tiberius group of manuscripts that were manufactured in southern England in the 8th and 9th centuries AD associated with the Mercian hegemony in Anglo-Saxon England. This Anglo-Saxon manuscript is considered to be the most sophisticated and elaborate of this group. The Book of Cerne exhibits various Irish/Celtic, Anglo-Saxon, Continental, and Mediterranean influences in its texts, ornamentation, and embellishment.

In Christian theology, the Harrowing of Hell is the period of time between the Crucifixion of Jesus and his resurrection. In triumphant descent, Christ brought salvation to the souls held captive there since the beginning of the world.