Bothwell Castle is a large medieval castle, sited on a high, steep bank, above a bend in the River Clyde in South Lanarkshire, Scotland. It is located between Bothwell and Uddingston, about 10 miles (16 km) south-east of Glasgow. Construction of the castle was begun in the 13th century by the ancestors of Clan Murray, to guard a strategic crossing point of the Clyde. Bothwell played a key role in Scotland's Wars of Independence, changing hands several times.

The River Clyde is a river that flows into the Firth of Clyde in Scotland. It is the ninth-longest river in the United Kingdom, and the second or third longest in Scotland. It runs through the major city of Glasgow. Historically, it was important to the British Empire because of its role in shipbuilding and trade. To the Romans, it was Clota, and in the early medieval Cumbric language, it was known as Clud or Clut. It was central to the Kingdom of Strathclyde.