Bottrop Hauptbahnof is a railway station in Bottrop, North Rhine-Westphalia, Germany. It is located on the Oberhausen-Osterfeld Süd – Hamm railway and Essen–Bottrop railway and is served by RE and S-Bahn services operated by DB and NordWestBahn.

The Oberhausen-Osterfeld Süd–Hamm railway, also called the Hamm-Osterfeld line, is a 76-kilometre long double-track electrified main line railway at the northern edge of the Ruhr in the German state of North Rhine-Westphalia.