Brendan Mikkelson is a Canadian former professional ice hockey defenceman who last played for Welsh team Cardiff Devils in the UK Elite Ice Hockey League (EIHL). He was a second round selection of the Mighty Ducks of Anaheim, 31st overall, at the 2005 NHL Entry Draft. He was a member of the 2007 Memorial Cup-winning Vancouver Giants team, and was named a tournament all-star on defence.

The 2005 NHL Entry Draft was the 43rd NHL Entry Draft. Originally scheduled to be held on June 25, the 2004–05 NHL lockout led to the draft being postponed to July 30.