Brent Cross is a major traffic interchange and area in the London Borough of Barnet, England. Originally the name of a crossroads, it is located a mile from the centres of Hendon and Golders Green. Notably, the Brent Cross Shopping Centre, a major retail facility, was opened in 1976, south of the interchange. The "Brent Cross Flyover" A41 runs to the east of the shopping centre over the A406 North Circular Road, while the M1 motorway and A5 Edgware Road are to the west at Staples Corner interchange. In addition, the Northern line and Thameslink rail routes run on viaducts.

The London Borough of Barnet is a local authority area on the northern outskirts of London. The borough was formed in 1965 from parts of the ceremonial counties of Middlesex and Hertfordshire. It is the second largest London borough by population with 389,344 inhabitants as of 2021, also making it the 17th largest district in England. The borough covers an area of 86.74 square kilometres (33 sq mi), the fourth highest of the 32 London boroughs, and has a population density of 45.8 people per hectare, which ranks it 25th.